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Tetracyclines: Concomitant treatment with Accutane and tetracyclines should be avoided because Accutane use has been associated with a number of cases of pseudotumor cerebri (benign intracranial hypertension), some of which involved concomitant use of tetracyclines.
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Isotretinoin (INN) (pronounced /a?so?tr??t?no??n/ or /?a?so?tr??t?no??n/[1]) is a medication used for the treatment of severe acne. It is sometimes used as a chemotherapy medication for prevention and treatment of certain skin cancers. In some cases, it is used to treat Harlequin type ichthyosis. It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body. Oral isotretinoin is marketed under various trade names, most commonly Accutane (Roche), Amnesteem (Mylan), Claravis (Barr), Decutan (Actavis), Isotane (Pacific Pharmaceuticals), Sotret (Ranbaxy), Oratane (Genepharm Australasia) or Roaccutane (Roche); while topical isotretinoin is most commonly marketed under the trade names Isotrex or Isotrexin Prior to the development of isotretinoin, the mainstay treatment of moderate to severe or persistent acne was oral antibiotics such as the tetracyclines and erythromycin. While these drugs have proven efficacy, they worked against only one contributing factor of acne – the Propionibacterium acnes bacteria. The antibiotics gradually became less effective over time as more resistant strains of the bacterium became prominent.
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Side effects that are common are listed here. Chapped lips (90%), countered by a using Vaseline or Aquaphor as a lip moisturizer, Dry skin and itching (80%) helped by frequent moisturizer creams, Dryness of nose, mild nosebleed (80%), helped by "AYR nasal gel", Irritation of the eyelids and eyes (40%), Joint and muscle pains (15%), Temporary hair thinning (10%), Rash (7%), Intestinal symptoms (5%), Urinary symptoms (5%), Headache (5%), Increased sensitivity to sun (5%), Decreased night vision (<1%), Depression, thoughts of suicide (<1%).